AKI on CKD – what we know
- AKI and CKD are interconnected syndromes
- On one hand, AKI contributes to the initiation and progression of CKD
- And the risk of CKD depends on the severity of AKI
- On the other hand, CKD predisposes patients to AKI
- AKI on CKD has a poor prognosis
- Increased proteinuria is also strongly associated with AKI on CKD
- AKI and longer term decline in renal function, is associated with pre-existing severity of CKD, higher stage of AKI, and cumulative number of AKI episodes
- While much has learned about AKI-CKD transition, the underlying mechanism of AKI on CKD remains largely elusive
- Elucidation of the mechanisms of AKI on CKD may identify effective therapeutic targets to reduce AKI and promote kidney repair and recovery in CKD patients.
Other resources
These are good review articles: He, 2017 and Hsu, 2017
Last Reviewed on 13 April 2024