Dr Andy Stein

Factors affecting efficacy (in terms of weight loss) of GLP-1 agonists

Factors affecting efficacy (in terms of weight loss) of GLP-1 agonists A recent study from the USA identified key factors that can impact the long-term weight loss of patients with obesity who were prescribed injectable semaglutide or liraglutide for the treatment of type 2 diabetes or obesity (Gasoyan, 2024). Key points In the study, the

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Weight loss drug’s heart benefits extend to people with heart failure

Weight loss drug’s heart benefits extend to people with heart failure In a recent study (Lincoff, 2023) in The Lancet, found similar cardiovascular benefits for a subgroup of study participants who were also judged to have heart failure at the start of the trial. Why is this important? Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist,

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Sodium bicarbonate treatment and clinical outcomes in CKD with metabolic acidosis: a meta-analysis

Sodium bicarbonate treatment and clinical outcomes in CKD with metabolic acidosis: a meta-analysis In a recent study by Ting-Ya, 2024, 14 studies looking at the effects of sodium bicarbonate on outcomes in CKD were combined, in what is called a meta-analysis. Why is this important? In patients with chronic kidney disease (CKD), impaired acid excretion

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Association of deprivation on outcomes in people with chronic kidney disease (CKD)

Association of deprivation on outcomes in people with chronic kidney disease (CKD) In a recent study by Al-Chalabi, 2024 the association of CKD with deprivation was investigated. Why is this important? Due to the high correlation of chronic kidney disease (CKD) with other comorbidities (e.g. diabetes/obesity), the effect of CKD on deprived people is not clear.

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What is the meaning of fluid overload (hypervolaemia)?

What is the meaning of fluid overload (hypervolaemia)? Fluid overload, also known as hypervolaemia, is a medical condition characterised by an excessive accumulation of fluid in the body. Treatment aims to the amount of fluid in your body. Pulmonary oedema on CXR, with pleural effusion arrowed. Here are 10 key facts about fluid overload. 1.

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