Long-term outcomes in IgA nephropathy In a recent UK study by Pitcher (2023), a large number of patients with IgA nephropathy were followed up for nearly six years (on average). Typical glomerulus in a kidney biopsy of a patient with IgA nephropathy. Why is this important? IgA nephropathy is a chronic glomerulonephritis (autoimmune disease) that […]
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4 advances in AI and nephrology in 2023 In a recent review (Shickel, 2024) 4 advances in how A1 may advance nephrology were described. The launch of ChatGPT1 was an important step in the democratisation of artificial intelligence (AI); similar systems will have a critical role in shaping future research and AI-augmented clinical practice in
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Genetic type and size of kidneys predict outcome in PKD Why is this important? Patients with polycystic kidney disease (PKD) can develop CKD, and some will proceed to kidney failure and need dialysis or a kidney transplant. The main objective of a recent study (Chen, 2023), was to identify factors predictive of rapid disease progression
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Pruritus and clinical outcomes in CKD patients not on dialysis Why is this important? Itching is a frequent symptom experienced by people with chronic kidney disease (CKD). In a recent study by Scherer, 2023 the associations of CKD-associated pruritus (CKD-aP) with clinical outcomes were investigated. What did the study show? 4,410 patients from Brazil, France,
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Risk factors for fractures after renal transplantation In a recent study by Tsai, 2003, this issue was investigated. Why is this important? Kidney transplant recipients are at an increased risk of fractures, and preventive strategies are needed. Therefore, the authors of this study investigated a large population to identify risk factors for fractures in Taiwanese kidney
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Kidney transplantation with a thin membrane nephropathy donor: a case report Pasilan, 2023 reported this unusual case recently. Kidney transplant from an identical, or monozygotic, twin usually possesses an excellent immunological match and provides the opportunity to minimise or even avoid immunosuppression toxicity. However, there are concerns regarding disease recurrence among end stage renal disease
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Itching in haemodialysis patients: what’s it related to? Why is this important? Itching (pruritus) is one of the most uncomfortable symptoms in kidney failure. The causes remain elusive. In a recent study by Sukul, 2023 traditional associations (dialysis dose, renal bone disease) were investigated. What did this study show? 7,976 haemodialysis patients across 21 countries,
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In a recent study by Shen, 2023 patients with combined anti-GBM disease and IgA nephropathy were studied. They are both causes of glomerulonephritis. Why is this important? The combination of anti–glomerular basement membrane (GBM) disease and immunoglobulin A nephropathy (IgAN) is unusual but known to occur. Therefore Shen and colleagues studied such patients. What did
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In a recent paper by Gandhi, 2023, a patient with COVAN (COVID-19-associated nephropathy) was described. The term ‘COVAN’ has been used to describe collapsing focal segmental glomerulosclerosis (FSGS) in people who have been infected with SARS-CoV-2. This helps differentiate it from the majority of cases of acute kidney injury in COVID-19 patients, which are typically
